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Patients with rheumatoid arthritis.
Suburbs of Copenhagen.
Other towns with ?100,000 inhabitants.
Towns with 10,000 to 99,999 inhabitants.
Rural areas/towns with <10,000 inhabitants.
No post-school education.
Semi-skilled worker, short education (<1 year) or apprentice.
Short or middle length advanced studies (1 to 4 years)
Long advanced studies (>4 years)
a Age in controls calculated as pseudo-year of diagnosis minus birth year. b One control had missing information about education.
Risk factors for RA overall.
Reproductive factors.
Reproductive factors in women and risk of rheumatoid arthritis, Denmark 1998 to 2003.
Number of patients/controls.
Number of live-born children.
Test for homogeneity (p)
Test for homogeneity (p)
Test for homogeneity (p)
Test for homogeneity (p)
Test for homogeneity (p)
Due to missing values for some individuals, numbers do not always add up to 366 patients and 478 controls. a Adjusted for birth year and year or pseudo-year of RA diagnosis. b Among women with at least one child. c Among postmenopausal women without histories of hormone replacement therapy or surgical removal of the uterus or ovaries. d Among women age 45 years or older. CI, confidence interval; OR, odds ratio; ref, reference.
Marital status and sexual behaviour.
Marital status, sexual behavior, and venereal diseases and risk of rheumatoid arthritis, Denmark 1998 to 2003.
Number of patients/controls.
Number of patients/controls.
Married or cohabiting with partner.
Divorced or separated.
Test for homogeneity (p)
Lifetime number of sexual partners of opposite sex.
Age at first sexual intercourse.
Lifetime number of anal-intercourse partners of opposite sex.
Test for homogeneity (p)
Due to missing values for some individuals, numbers do not always add up to 366 female and 149 male patients with RA and 478 female and 291 male controls. a Adjusted for birth year, year or pseudo-year of RA diagnosis, and (when combined) gender. b One or more of the following: chlamydia, herpes, acuminate condylomas, gonorrhea, or syphilis. CI, confidence interval; OR, odds ratio; ref, reference.
Smoking, coffee, alcohol, diet, body mass index, physical activity, and pets.
Tobacco smoking, coffee and alcohol intake, body mass index, physical activity, and pets and risk of rheumatoid arthritis, Denmark 1998 to 2003.
Number of patients/controls.
Number of patients/controls.
Test for homogeneity (p)
>0 to 10 pack-years.
>10 to 20 pack-years.
>0 to 5 cups per day.
>5 to 10 cups per day.
>10 cups per day.
0 drinks per week.
>0 to 5 drinks per week.
>5 to 10 drinks per week.
>10 to 15 drinks per week.
>15 drinks per week.
0 glasses per week.
>0 to 5 glasses per week.
>5 to 10 glasses per week.
>10 to 15 glasses per week.
>15 glasses per week.
<18.5 kg/m 2 (underweight)
18.5 to < 25 kg/m 2 (normal weight)
25 to < 30 kg/m 2 (overweight)
Body mass index at age 20.
<18.5 kg/m 2 (underweight)
18.5 to <25 kg/m 2 (normal weight)
25 to <30 kg/m 2 (overweight)
Not physically demanding.
Slightly physically demanding.
Moderately physically demanding.
Very physically demanding.
Trend test (p) e,f.
Not physically demanding.
Slightly physically demanding.
Moderately physically demanding.
Very physically demanding.
Test for homogeneity (p)
Due to missing values for some individuals, numbers do not always add up to 366 female and 149 male patients with RA and 478 female and 291 male controls. a Adjusted for birth year, year or pseudo-year of RA diagnosis, and (when combined) gender. b One pack-year is equivalent to 7,300 cigarettes (20 cigarettes per day for 1 year). c Ten years prior to interview. d One drink is equivalent to one bottle of normal beer, 0.67 bottle of strong beer, or one glass of wine, dessert wine, or spirits. e Trend tests on the original categories, which were enumerated by consecutive numbers starting with one. f Including only individuals who had a job. CI, confidence interval; OR, odds ratio; ref, reference.
Viral antibodies in serum and self-reported health conditions.
Self-reported health conditions and risk of rheumatoid arthritis, Denmark 1998 to 2003.
Number of patients/controls.
Number of patients/controls.
0.63 (0.33 to 1.20) b.
0.58 (0.36 to 0.93) e.
Stomach or duodenal ulcer.
0.73 (0.47 to 1.16) b.
2.84 (0.22 to 36.05)
2.32 (0.35 to 15.44)
1.52 (0.94 to 2.46) b.
0.73 (0.57 to 0.95) e.
5.51 (0.89 to 34.19)
Tonsillectomy, adenoidectomy, appendectomy, or splenectomy.
Schizophrenia among first-degree relatives.
2.08 (0.88 to 4.93) b.
Numbers of patients and controls refer to participants who ever had the health condition in question. a ORs represent comparisons between ‘ever’ versus ‘never’ (= reference) for each presented disease, with adjustment for birth year, year or pseudo-year of RA diagnosis, and (when combined) gender. b Test for homogeneity 0.05 < p < 0.20. c Physician-verified diagnosis. d Asthma before age 45 years. e Test for homogeneity p < 0.05. CI, confidence interval; OR, odds ratio.

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